Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Mental health
RCT	61 people with CFS (CDC criteria) In review	Self-reported anxiety symptoms (mean change in Hospital Anxiety and Depression scale [HADS] anxiety score) 12 weeks 1.6 with graded exercise therapy 0.9 with control intervention (flexibility and relaxation training)	P = 0.2		Not significant
RCT	61 people with CFS (CDC criteria) In review	Self-reported depressive symptoms (mean change in HADS depression score) 12 weeks 1.7 with graded exercise therapy 0.6 with control intervention (flexibility and relaxation training)	P = 0.04	Effect size not calculated	graded exercise therapy
RCT	22 adolescents wit CFS (Fuduka critera) In review	Depression (assessed by Becks Depression Index) change from baseline to 4 weeks –4.2 with graded exercise therapy –6.7 with control intervention (progressive resistance training)	P = 0.40		Not significant
RCT 4-armed trial	641 adults with CFS (Oxford criteria)	Depression (assessed by HADS score) 52 weeks 6.1 with graded exercise therapy 7.2 with specialist medical care	P = 0.0035	Effect size not calculated	graded exercise therapy
RCT 4-armed trial	641 adults with CFS (Oxford criteria)	Anxiety (assessed by HADS score) 52 weeks 7.1 with graded exercise therapy 8.0 with specialist medical care	P = 0.0142	Effect size not calculated	graded exercise therapy