Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Depression
RCT	107 depressed and non-depressed people with CFS (Oxford criteria) In review	Improvement in the Beck Depression Inventory 8 weeks with fluoxetine with placebo Absolute results not reported	Mean difference –0.19 95% CI –0.35 to –0.02 The difference is small, and possibly not clinically important	Effect size not calculated	fluoxetine
4-armed trial	136 people with CFS (Oxford criteria) In review	Mean change in Hospital Anxiety and Depression scale (HADS) score 12 weeks with fluoxetine with placebo Absolute results not reported	Mean difference 1.10 95% CI 0.03 to 2.20	Effect size not calculated	fluoxetine