Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Withdrawal
RCT	100 people with neurally mediated hypotension and CFS (CDC criteria) In review	Withdrawal because of adverse effects 9 weeks 12/50 (24%) with fludrocortisone (titrated to 0.1 mg/day) 4/50 (8%) with placebo	RR 3.00 95% CI 1.04 to 8.67 NNH 6 95% CI 3 to 8	Moderate effect size	placebo
RCT Crossover design	25 people with CFS (CDC criteria) In review	Withdrawal rate 3 people with fludrocortisone 1 person with placebo	Results should be interpreted with caution, as it is possible that treatment effects may persist after crossover