Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Fatigue
RCT Crossover design	32 people with CFS In review	Mean change in fatigue score from baseline (patient-assessed 11-item scale, overall score 0–33, higher score indicates greater fatigue) 1 month –6.7 with hydrocortisone (5 or 10 mg/day) –2.4 with placebo Absolute numbers not reported	Significance not assessed Benefit from hydrocortisone may be short-term; see Further information on studies for full details