Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Fatigue
RCT Crossover design	100 people with CFS (CDC criteria) In review	Mean visual analogue scale (VAS) fatigue score (0 = no fatigue to 10 = severe fatigue) 3 months 6.6 with hydrocortisone 5 mg daily plus fludrocortisone 50 micrograms daily 6.7 with placebo	P = 0.76 Results should be interpreted with caution, as it is possible that treatment effects may persist after crossover		Not significant
RCT Crossover design	100 people with CFS (CDC criteria) In review	Mean score on Abbreviated Fatigue Questionnaire 3 months 8 with hydrocortisone 5 mg daily plus fludrocortisone 50 micrograms daily 7 with placebo	P = 0.69 Results should be interpreted with caution, as it is possible that treatment effects may persist after crossover		Not significant