Table 1.
Results for the screening questions for 642 individuals with results available for LRRK2 G2019S genetic testing
| Question | Response | Number of responses (%) | No. LRRK2 G2019S+ (%) (n = 72) | No. LRRK2 G2019S− (%) (n = 570) |
|---|---|---|---|---|
| 1. Do you have Parkinson disease? | Yes | 305 (47.5) | 38 (52.8) | 267 (46.8) |
| No | 337 (52.5) | 34 (47.2) | 303 (53.2) | |
| 2. Have you previously been tested for a possible LRRK2 gene mutation? (no report found to be available) | Yes | 13 (2.0) | 5 (6.9) | 8 (1.4) |
| No | 582 (90.7) | 60 (83.3) | 522 (91.6) | |
| Do not know | 47 (7.3) | 7 (9.7) | 40 (7.0) | |
| 3. Are you of Eastern European (Ashkenazi) Jewish descent? | Yes | 579 (90.2) | 67 (93.1) | 512 (89.8) |
| No | 43 (6.7) | 3 (4.2) | 40 (7.0) | |
| Do not know | 20 (3.1) | 2 (2.3) | 18 (3.2) | |
| 4. Are you of Basque (Northern Spain) descent? (newer question, 356 responding) | Yes | 3 (0.8) | 0 (0.0) | 3 (0.5) |
| No | 335 (94.1) | 35 (48.6) | 300 (52.6) | |
| Do not know | 18 (5.1) | 4 (5.6) | 14 (2.5) | |
| 5. Do any of the following also have PD? | Father | 222 (34.6) | 26 (36.1) | 196 (34.4) |
| Mother | 161 (25.1) | 25 (34.7) | 136 (23.9) | |
| Brother | 50 (7.8) | 5 (6.9) | 45 (7.9) | |
| Sister | 35 (5.5) | 5 (6.9) | 30 (5.3) | |
| Children | 9 (1.4) | 1 (1.4) | 8 (1.4) | |
| 6. Do you have a first-degree relative (father, mother, full sibling, child) with a positive LRRK2 gene test? | Yes | 57 (8.9) | 12 (16.7) | 44 (7.7) |
| No | 143 (22.3) | 14 (19.4) | 129 (22.6) | |
| Do not know | 443 (69.0) | 46 (63.9) | 397 (69.6) |