Table 3.
Locations of supraspinal peak activation during the different micturition-related conditions
| Voiders (n = 14) |
Nonvoiders (n = 7) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | BA | HEM | t-value | MNI coordinates (mm) |
Region | BA | HEM | t-value | MNI coordinates (mm) |
||||
| x | y | z | x | y | z | ||||||||
| IMITATE | |||||||||||||
| P <0.01 cluster-corrected, k >106 | |||||||||||||
| IFG | 46 | LH | 4.13 | −48 | 45 | 3 | CT | n/a | LH | 3.98 | −36 | −75 | −30 |
| MFG | 10 | LH | 4.66 | −45 | 48 | −9 | MTG | 21 | RH | 6.18 | 57 | −51 | 3 |
| STG (temporopolar) | 38 | LH | 5.00 | −54 | 12 | −9 | STG (temporopolar) | 38 | RH | 4.61 | 57 | 15 | −6 |
| CT | n/a | LH | 4.64 | −36 | −57 | −36 | SMG | 40 | RH | 4.56 | 51 | −48 | 30 |
| CT | n/a | RH | 4.39 | 42 | −57 | −33 | MFG | 47 | RH | 4.5 | 48 | 45 | −9 |
| STG (temporopolar) | 38 | RH | 3.89 | 57 | 12 | −6 | Insula | 13 | RH | 4.31 | 38 | 15 | 9 |
| INITIATE-E | |||||||||||||
| P < 0.01 cluster-corrected, k > 106 | |||||||||||||
| IFG | 45 | LH | 3.00 | −33 | 24 | 3 | Cerebellum | n/a | LH | 3.36 | −18 | −36 | −24 |
| brainstem/PAG | n/a | LH | 2.90 | −6 | −15 | −6 | |||||||
| IFG | 45 | RH | 3.39 | 63 | 18 | 18 | |||||||
| Insula (anterior) | 13 | RH | 3.31 | 36 | 18 | 9 | |||||||
| INITIATE-L | |||||||||||||
| P < 0.001 (FDR corrected), cluster-corrected, k > 106 | P < 0.01 cluster-corrected, k > 106 | ||||||||||||
| PoCG (OP 1) | 40 | LH | 6.67 | −57 | −27 | 18 | PoCG (OP 4) | 43 | LH | 4.85 | −63 | −12 | 18 |
| CT | n/a | LH | 5.15 | −42 | −51 | −39 | PHG | 30 | LH | 3.34 | −18 | −51 | 0 |
| Thalamus (VPL) | n/a | LH | 4.77 | −18 | −18 | 6 | aMCC (ROI 6) | 24 | LH | 3.34 | −6 | 9 | 27 |
| MTG | 37 | LH | 5.37 | −51 | −63 | 3 | IPL | 40 | LH | 4.43 | −41 | −36 | 48 |
| MFG | 9 | LH | 5.29 | −30 | 30 | 36 | STG | 22 | LH | 4.59 | −57 | 0 | 0 |
| PreCG | 6 | LH | 4.8 | −57 | 6 | 14 | pMCC (ROI 8) | 6 | RH | 3.24 | 3 | −12 | 51 |
| MFG | 47 | RH | 7.29 | 48 | 45 | −6 | STG (temporopolar) | 38 | RH | 5.95 | 48 | 12 | −18 |
| PoCG (OP 4) | 40 | RH | 7.18 | 63 | −18 | 18 | PCC (ROI 12) | 30 | RH | 3.68 | 24 | −60 | 6 |
| PCC (ROI 10) | 31 | RH | 5.51 | 12 | −30 | 42 | SFG | 10 | RH | 5.54 | 36 | 54 | 24 |
| Pons (PMC) | n/a | RH | 5.48 | 6 | −30 | −24 | SFG | 9 | RH | 4.35 | 18 | 54 | 24 |
| Precuneus | 7 | RH | 4.59 | 15 | −72 | 48 | MTG | 21 | RH | 4.48 | 63 | −51 | 3 |
| IPL | 40 | RH | 5.01 | 63 | −39 | 24 | |||||||
| SMG | 40 | RH | 4.59 | 54 | −48 | 18 | |||||||
| URINATE | |||||||||||||
| P < 0.01 cluster-corrected, k > 106 | |||||||||||||
| CT | n/a | RH | 3.47 | 30 | −57 | −45 | |||||||
| STOP | |||||||||||||
| P < 0.01 cluster-corrected, k > 106 | |||||||||||||
| ACC | 32 | LH | 4.99 | −12 | 42 | 6 | |||||||
| Cerebellum | n/a | LH | 3.57 | −3 | −42 | −9 | |||||||
| PAG | n/a | RH | 3.57 | 3 | −27 | −15 | |||||||
Notes: The supraspinal foci of BOLD-signal increase during the different conditions compared with REST within both groups, (voiders and nonvoiders). In voiders all 5 conditions (IMITATE, INITIATE-E, INITIATE-L, URINATE, and STOP) were applicable, whereas in nonvoiders only 3 conditions (IMITATE, INITIATE-E, and INITIATE-L) were applicable.
The specifications relating to ROI (region of interest) determination in cingulate cortex areas is based on the study of Torta and Cauda (2011).
ACC, anterior cingulate cortex; aMCC, anterior midcingulate cortex; BA, Brodmann area; CT, cerebellar tonsil; HEM, hemisphere; IFG, inferior frontal gyrus; LH, left hemisphere; IPL, inferior parietal lobe; MFG, middle frontal gyrus; MNI, Montreal Neurological Institute; MTG, middle temporal gyrus; OP, parietal operculum; PAG, periaqueductal gray; PCC, posterior cingulate cortex; PHG, parahippocampal gyrus; PMC, pontine micturition center; pMCC, posterior midcingulate cortex; PoCG, postcentral gyrus; PreCG, precentral gyrus; RH, right hemisphere; SMG, supramarginal gyrus; STG, superior temporal gyrus; VPL, ventral posterolateral nucleus.