Figure 5.

THIP reduces the I-IC epileptiform activity in acute slices from Syn II^−/− mice. (a) Raster plots depicting I-IC activities induced by 100 μM 4-AP and recorded over the entire 4096 electrode field in WT (black frame) and Syn II^−/− (gray frame) slices before and after THIP treatment. Note the reduction in the frequency of I-IC events induced by THIP in the Syn II^−/− networks. (b) Representative traces showing 4-AP-induced I-IC activities in the EC and DG of WT and Syn II^−/− slices before and after the administration of 1 μM THIP. Traces are taken from one representative electrode per area. (c) The application of 1 μM THIP reduces the increased frequency of I-IC events in Syn II^−/− slices to WT levels. *P < 0.05 across genotype; ⁺⁺P < 0.01, effect of treatment within genotype; two-way ANOVA followed by the Bonferroni's post hoc test.