Table 2.
Structural connectivity differences in local efficiency (× 10−3)
| Local efficiency (× 10−3) | FCa | FtMb | MCc | MtFd |
|---|---|---|---|---|
| Full and sparse matrices | ||||
| Precentral gyrus L | 5.0 ± 1.5(c) | 5.2 ± 1.4 | 4.9 ± 1.7(a) | 6.4 ± 1.8aa,b,c |
| Postcentral gyrus L | 4.2 ± 1.3(d) | 4.1 ± 1.2c,d | 4.0 ± 1.3(d) | 4.9 ± 1.4(a),(c) |
| Inferior occipital gyrus L | 1.4 ± 0.7b,d | 1.1 ± 0.6a,cc,ddd | 1.8 ± 1.0bb | 2.0 ± 1.0a,bbb |
| Insula R | 10.5 ± 4.7 | 6.8 ± 2.5aaa,c,ddd | 10.5 ± 4.5 | 11.4 ± 3.5 |
| Inferior orbitofrontal cortex R | 4.5 ± 2.6(c) | 3.1 ± 1.5a,cc,dd | 4.6 ± 2.1(a) | 4.9 ± 1.9 |
| Full matrices only | ||||
| Insula L | 10.3 ± 3.9(b),(d) | 8.6 ± 3.4(a),dd | 9.6 ± 3.5d | 12.3 ± 3.7(a),bb,c |
| Inferior frontal g., triang. L | 3.9 ± 1.7(c) | 3.7 ± 2.0(c) | 3.9 ± 1.8(a),(b),(d) | 5.1 ± 1.9a,b,(c) |
| Supplementary motor area L | 5.8 ± 1.6 | 5.8 ± 2.1 | 5.2 ± 2.1 | 7.2 ± 2.3a,(b),cc |
| Paracentral gyrus L | 3.8 ± 1.7 | 4.0 ± 1.4 | 3.2 ± 1.6 | 4.7 ± 2.0c |
| Precuneus L | 6.7 ± 3.0 | 5.7 ± 2.9(c) | 6.4 ± 2.8(b) | 8.2 ± 3.3b,c |
| Supramarginal gyrus L | 2.5 ± 0.6(b) | 3.1 ± 1.9(a) | 3.0 ± 1.1 | 3.8 ± 1.5aaa,b,c |
| Superior temporal gyrus L | 3.6 ± 1.4 | 3.2 ± 1.5 | 3.6 ± 1.3 | 4.8 ± 3.7(a),b,cc |
| Inferior frontal g., triang. R | 4.4 ± 2.5(b),c,(d) | 3.4 ± 1.9(a),cc,dd | 4.4 ± 2.5a,bb | 4.9 ± 2.0(a),bb |
| Inferior frontal g., opercul. R | 3.7 ± 1.4c,dd | 3.7 ± 0.2(c),d | 4.0 ± 1.4a,(b) | 4.6 ± 1.3aa,b |
| Precentral gyrus R | 4.8 ± 1.6c,dd | 4.5 ± 1.4c,dd | 5.1 ± 1.5a,b,(d) | 6.1 ± 1.8aa,bb,(c) |
| Supramarginal gyrus R | 2.2 ± 0.7cc,dd | 2.3 ± 1.3c,d | 2.8 ± 1.1aa,b | 3.2 ± 1.0aa,b |
| Superior temporal gyrus R | 3.7 ± 1.7 | 2.7 ± 1.2a,c,dd | 3.6 ± 1.5(d) | 4.4 ± 2.0(c) |
| Inferior occipital gyrus R | 1.3 ± 0.7(b),c | 1.0 ± 0.5(a),cc,d | 1.7 ± 0.9a,bb,(d) | 1.4 ± 0.6b,(c) |
| Sparse matrices only | ||||
| Lingual gyrus L | 19.5 – 4.3 | 17.5 – 3.5 | 16.8 – 4.0 | 23.9 – 5.6(a),bb,c |
| Calcarine gyrus L | 22.1 – 5.2(b) | 20.8 – 4.3(a),(c) | 20.8 – 4.9(b) | 32.0 – 6.6(a),bb,c |
| Angular gyrus L | 61.5 – 8.3 | 57.0 – 7.1 | 57.8 – 7.4 | 74.1 – 10.4b,c |
| Superior parietal gyrus L | 57.9 – 6.7 | 52.0 – 5.9(c),d | 57.7 – 6.3 | 69.3 – 8.8 |
| Olfactory cortex R | 54.2 – 6.3 | 39.1 – 4.7aa,(c),dd | 53.7 – 5.9 | 61.6 – 7.3 |
| Inferior temporal gyrus R | 35.0 – 5.7 | 26.0 – 4.3a,c,dd | 35.8 – 5.4 | 39.7 – 6.3 |
| Middle temporal pole R | 41.4 – 8.3 | 37.8 – 6.4a,d | 48.9 – 7.4 | 58.5 – 8.7 |
| Superior temporal pole R | 58.9 – 8.7 | 46.2 – 6.6a,c,dd | 63.0 – 8.4 | 72.6 – 9.2 |
Note: Full matrices are unthresholded; results from sparse (i.e., thresholded) matrices are considered if significance is observed in at least 7 of 9 levels of sparsity. Superscript characters indicate significant differences of 1 group as compared with female (FCa) or male controls (MCb), female-to-male (FtMc) or male-to-female transsexuals (MtFd).
Triang., triangular part; opercul., opercular part; L, left; R, right.
Bold values denote significance at aP < 0.05, aaP < 0.01, and aaaP < 0.001, trends for statistical significance are denoted in brackets (a). If only 1 group shows significant differences, characters are only indicated there. Raw values are given as mean ± standard deviation (full matrices) and as mean for 10–50% sparsity (sparse matrices); significant differences include correction for TIV.