Table 3. Univariate and multivariate analyses of the HBV-ACLF cohort.

	Univariate analysis			Multivariate analysis#
	P	HR	95%CI	P	HR	95%CI
Gender (male vs female)	0.283	0.614	0.252–1.495
Age (years)	0.005	1.048	1.014–1.083
BMI (kg/m2)	0.371	1.056	0.937–1.191
ALT (IU/L)	0.261	1.001	1.000–1.002
AST (IU/L)	<0.001	1.004	1.002–1.006
WBC (×109/L)	<0.001	1.109	1.059–1.161
hemoglobin (g/L)	0.140	1.012	0.996–1.028
albumin (g/L)	0.898	1.005	0.931–1.085
BPC (×109/L)	0.322	0.995	0.986–1.005
TB (μmol/L)	0.002	1.003	1.001–1.005
Cr (μmol/L)	0.053	1.007	1.000–1.014
INR	0.001	2.516	1.430–4.425
Sodium (mmol/L)	0.146	0.952	0.891–1.017
HBeAg positive (yes vs no)	0.035	0.446	0.211–0.946
Log10HBV-DNA (IU/mL)	0.002	1.336	1.108–1.612
M30-antigen (U/L)*	<0.001	3.864	2.408–6.200	0.044	2.027	1.683–2.371
M65-antigen (U/L)*	<0.001	4.910	2.662–9.057	0.039	2.431	2.008–2.854
HMGB1 (ng/mL)	0.464	1.013	0.978–1.049
MELD	<0.001	1.137	1.070–1.209	0.0016	1.118	1.083–1.153
CTPs	0.012	1.311	1.060–1.622

Abbreviation: WBC, white blood cell, BPC, blood platelet counts; TB, total bilirubin; Cr, Creatinine; INR, international normalized ratio; HBeAg, hepatitis B e antigen.

^#Variables identified as P < 0.05 in univariate analyses were further analyzed in multivariate analysis.

*Log_e transformation.