Figure 3. LINGO-1 antibody restores the impairment of spatial learning and memory in EAE mice(a) LINGO-1 antibody significantly reduced the EAE clinical scores (P < 0.05).

(b) In the MWM, the mean escape latency of the EAE mice was significantly longer than the controls, and Anti-LINGO-1reduced the latency to the platform in treated EAE mice. (c) On the sixth day, there was no difference in the percent distance of the target quadrant among the three groups. (d) Further we evaluated the distance around the platform 10 cm and found that the distance covered by the EAE mice was significantly less than that of the control mice, whereas the LINGO-1 antibody-treated EAE mice covered more distance around the target quadrant than the EAE mice, but this difference was not significant. *Denotes statistical significance compared with controls (P < 0.05). ^#Denotes statistical significance compared with EAE mice without treatment (P < 0.05).