Table 2. The genes with altered expression in pre-eclamptic placentae in the RNA-seq.
| Gene symbol | Function | Protein localisation | Log2 FCAll pools | Log2 FCw/o PE1 | Log2 FCw/o PE3 | Up/Down |
|---|---|---|---|---|---|---|
| ACTA2 | Smooth muscle cell contractility | Cytoplasm | −1.31 | ↓ | ||
| ARMS2 | Unknown | Cytoplasm | 2.36 | 2.26 | 1.98 | ↑ |
| ARNT2 | Response to hypoxia | Nucleus | 1.50 | ↑ | ||
| BHLHE40 | Cell differentiation, growth suppression | Nucleus | 1.10 | ↑ | ||
| BTNL9 | Regulation of immune response | Membrane | 1.82 | ↑ | ||
| CCSAP | Cilia function, development | Cytoplasm | 1.20 | ↑ | ||
| CGB | Maintenance of pregnancy | Secreted | 1.82 | 1.33 | 2.21 | ↑ |
| CGB1 | Possibly implantation | Secreted | 1.30 | 1.39 | ↑ | |
| CGB2 | Possibly implantation | Secreted | 1.34 | 1.47 | ↑ | |
| CGB8 | Maintenance of pregnancy | Secreted | 1.22 | 1.15 | ↑ | |
| COL17A1 | Cell adhesion, negative regulation of cell motility | Membrane, secreted | 1.10 | ↑ | ||
| CORO2A | Inflammatory response | Cytoplasm | 1.86 | ↑ | ||
| CXCL9 | T-cell chemoattractant | Secreted | −3.10 | −3.04 | −2.93 | ↓ |
| CYP1A1 | PAH metabolism | Cytoplasm | −5.12 | ↓ | ||
| DEFA1 | Host defence | Cytoplasm, secreted | −2.69 | −3.18 | ↓ | |
| DEFA1B | Host defence | Cytoplasm, secreted | −2.68 | −3.17 | ↓ | |
| DIO2 | Activation of thyroid hormone | Cytoplasm | 1.59 | ↑ | ||
| FCGR3A | Antibody-dependent responses, natural killer cell cytotoxicity | Membrane, secreted | −1.31 | −1.26 | −1.28 | ↓ |
| FER1L4 | Long noncoding RNA, gene expression regulation | No protein product | 0.96 | ↑ | ||
| FSTL3 | Regulation of growth factor activity during development, metabolic homeostasis | Secreted | 1.35 | 1.50 | 1.33 | ↑ |
| HBB | Component of adult hemoglobin | Cytoplasm | −1.20 | −1.62 | ↓ | |
| HBG1 | Component of fetal hemoglobin | Cytoplasm | −1.12 | ↓ | ||
| HK2 | Glucose metabolism | Cytoplasm | 1.72 | 2.09 | ↑ | |
| HLA-DRA | Alpha subunit of HLA-DR, presenting antigens to T-cells | Membrane | −1.26 | −1.30 | −1.17 | ↓ |
| HPSE | Remodelling of extra-cellular matrix to permit cell movement | Secreted | 1.08 | ↑ | ||
| HTRA4 | Degradation of misfolded proteins | Secreted | 1.32 | 1.63 | 1.03 | ↑ |
| IGFBP1 | Binds to insulin-like growth factors, possibly restricts fetal growth | Secreted | 1.29 | ↑ | ||
| KRT6A | Epithelial structures, wound healing | Cytoplasm | −5.34 | −5.41 | −4.92 | ↓ |
| LEP | Fetal growth, reproduction, angiogenesis, suppression of appetite, regulation of immune response | Secreted | 2.26 | 2.67 | ↑ | |
| LGALS14 | Trophoblast differentiation | Nucleus | −0.98 | −1.05 | ↓ | |
| LOC100129345 | Unknown | No protein product | −1.09 | −1.35 | ↓ | |
| LYN | Immune response, response to growth factors, and cell proliferation, survival, differentiation, and migration | Cytoplasm | 1.05 | ↑ | ||
| LYPD5 | Unknown | Membrane | −1.28 | ↓ | ||
| LYZ | Antibacterial activity | Secreted | −1.22 | −1.22 | ↓ | |
| MAGEA4 | Promotion of cell growth | Cytoplasm | −1.71 | ↓ | ||
| MYO7B | Transport | Cytoplasm | 1.71 | 1.82 | ↑ | |
| NCMAP | Myelination | Membrane | −0.99 | ↓ | ||
| NDRG1 | Stress and hormone response, cell growth, differentiation, apoptosis | Nucleus | 1.08 | ↑ | ||
| NRIP1 | Modulation of transcriptional activity | Nucleus | 1.31 | ↑ | ||
| PLIN2 | Lipid accumulation, inhibition of cellular glucose uptake | Cytoplasm | 1.28 | ↑ | ||
| PSG10P | Unknown | No protein product | −1.15 | ↓ | ||
| PVRL4 | Cell adhesion | Membrane, secreted | 1.24 | ↑ | ||
| RPS17 | A component of the ribosomal 40S subunit | Cytoplasm | −1.40 | −1.37 | −1.34 | ↓ |
| S100A8 | Multiple functions in immune response, antioxidant function | Cytoplasm, secreted | −1.78 | ↓ | ||
| SASH1 | Inhibition of invasion, growth and proliferation, proinflammatory | Intracellular | 1.23 | 1.45 | ↑ | |
| SBSPON | Unknown | Secreted | −2.28 | ↓ | ||
| SERPINB9 | GranzymeB inhibition | Cytoplasm | 0.98 | 1.28 | ↑ | |
| SH3BP5 | Neuroprotection, reduction of oxidative stress | Cytoplasm | 1.11 | ↑ | ||
| SIGLEC6 | Binds leptin, affects proliferation, invasion and apoptosis | Membrane, secreted | 1.33 | ↑ | ||
| TET3 | DNA methylation process, epigenetic chromatin reprogramming | Nucleus | 1.30 | 1.61 | ↑ | |
| THY1 | T-cell cell surface glycoprotein | Membrane | −1.30 | ↓ | ||
| TPBG | Promigratory | Membrane | 1.05 | ↑ | ||
| ZNF175 | Suppression of viral replication | Nucleus | 1.30 | ↑ |
Log2 fold change (FC) is shown for the subanalyses where a trancript had a q value <0.05. PE = pre-eclampsia.