Table 3. Pathway analysis results from Gene Set Enrichment Analysis.
| Pathway | ES (+/−) | FDR q value |
||
|---|---|---|---|---|
| All pools | w/o PE1 | w/o PE3 | ||
| Allograft rejection | − | <0.001 | <0.001 | <0.001 |
| Interferon gamma response | − | <0.001 | <0.001 | <0.001 |
| Inflammatory response | − | <0.001 | <0.001 | 0.002 |
| Kras signalling up | − | <0.001 | <0.001 | 0.002 |
| Complement | − | 0.001 | 0.011 | 0.002 |
| IL6 JAK STAT3 signaling | − | 0.001 | 0.001 | 0.009 |
| Interferon alpha response | − | 0.002 | <0.001 | 0.018 |
| Epithelial mesenchymal transition | − | 0.009 | 0.001 | |
| Oxidative phosphorylation | − | 0.022 | 0.001 | |
| Xenobiotic metabolism | − | 0.023 | ||
| Coagulation | − | 0.026 | 0.038 | |
| Angiogenesis | − | 0.027 | 0.004 | |
| Bile acid metabolism | − | 0.035 | ||
| TNFa signalling via NFKb | − | 0.034 | ||
| Reactive oxygen species pathway | − | 0.038 | ||
| IL2 STAT5 signaling | − | 0.048 | 0.034 | |
| Protein secretion | − | 0.009 | ||
The hallmark gene sets were utilised in the analyses. ES = Enrichment score; a negative ES indicates gene set enrichment at the bottom of the ranked list i.e. the genes that were down-regulated in pre-eclampsia. FDR q value = a false discovery rate corrected p value, q values < 0.05 are shown in the table.