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. 2015 Sep 21;5:14259. doi: 10.1038/srep14259

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SRLF index of Met124 in the wild-type (WT) and Leu124 in the mutant (MUT; based on homology modeling) of CaM in the presence and absence (simply by separating the targets from CaM in the bound complexes) of the target are shown. The plot represents 15 CaM complexes for 9 different targets (CaMKK (Ca²⁺/CaM-dependent kinase kinase), CaMKI (Ca²⁺/CaM-dependent kinase I), MLCK (Ca²⁺/CaM-dependent myosin light chain kinase), PMCA (plasma membrane Ca²⁺-ATPase), CaV (voltage-activated Ca²⁺-channel), alphaII-spectrin, MUNC (mammalian uncoordinated proteins), SK2 (small conductance calcium-activated potassium 2 channel), and NHE1 (sodium/hydrogen exchanger 1)) in which Met124 is highly frustrated in the WT CaM for the target-bound complexes.