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. 2015 Sep 21;5:14274. doi: 10.1038/srep14274

Figure 4. Pre-treatment with NP-CpG reduces mucus production in lungs of allergic mice.

Figure 4

Mice were pre-treated with CpG and then sensitized and challenged with HDM as in Fig. 2A. (A) Representative periodic acid-Schiff (PAS)-stained lung sections showing mucus-producing goblet cells (dark magenta) within bronchi (scale bar, 100 μm). (B) Quantification of mucus-producing goblet cells per unit length. (C) Representative PAS-stained lung sections showing leukocyte accumulation (blue) around blood vessels (scale bar, 100 μm). (D) Inflammation score, defined as area of leukocyte infiltration and normalized to the average value in naïve mice. Data show mean ± SEM from three independent experiments, 14 mice per group (5 mice in naïve group). *P < 0.05, **P < 0.01; ##P < 0.01 compared to naïve mice.