Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 22;5:14076. doi: 10.1038/srep14076

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Top, schematic representation of upstream region of the PEPCK1 (left) and G6Pase (right) genes. Bottom, ChIP assays of SGK2, PXR and RXRα levels at PSRE (PEPCK1: −4,062/−3,916, G6Pase: −1,613/−1,593) and IRS (PEPCK1: −447/−298, G6Pase: −196/−156) regions in ShP51 cells treated with simvastatin (Simva, 10 μM) for 60 min (b) Time course ChIP assays of SGK2 and PXR levels at PSRE and IRS regions in ShP51 cells treated with simvastatin (Simva, 10 μM) for 15, 30, 45 and 60 min. (c) ChIP assays of SGK2 T193A and SGK2 T193Dlevels at PSRE and IRS regions in pcDNA/FLAG-SGK2 T193A or pcDNA/FLAG-SGK2T193D-transfected ShP51 cells treated with simvastatin (Simva, 10 μM) for 1 h. (d) ChIP assays of SGK2 and PXR levels at PSRE and IRS regions in human primary hepatocytes treated with simvastatin (Simva, 10 μM) for 3 h. Data shown were generated from three independent experiments.