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. 2015 Sep 22;5:14076. doi: 10.1038/srep14076

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Statin-activated PXR binds to SGK2 phosphorylated at threonine 193 and facilitates dephosphorylation by PP2Cα. Subsequently, these PXR and dephosphorylated SGK2 bind PSRE and IRS within the promoter to activate it.