Table 3. Summary ORs and 95% CI of the C150T(Ser608 Leu) Polymorphism and the polymorphic (CCTTT)n repeats in the inducible nitric oxide synthase Gene and Cancer Risk.
| Statistical models | Genotype/Allele | Numberof Study | OR | 95%CI | I2% | P | Z | P forZ test |
|---|---|---|---|---|---|---|---|---|
| C150T(Ser608 Leu) | ||||||||
| Allele Model | T vs. C | 5 | 0.94 | 0.81-1.08 | 0 | 0.83 | 0.88 | 0.38 |
| Codominant model | TT vs. CC | 5 | 0.77 | 0.49-1.21 | 0 | 0.41 | 1.12 | 0.26 |
| TT vs. CT | 5 | 0.82 | 0.52-1.30 | 22 | 0.28 | 0.84 | 0.4 | |
| Recessive model | TT vs. CT+CC | 5 | 0.79 | 0.51-1.24 | 12 | 0.34 | 1.01 | 0.31 |
| Dominant model | TT+CT vs. CC | 6 | 0.93 | 0.80-1.09 | 0 | 0.89 | 0.87 | 0.39 |
| Subgroup | ||||||||
| C150T(Ser608 Leu) in Asian | ||||||||
| Allele Model | T vs. C | 3 | 1.04 | 0.82-1.32 | 0 | 0.90 | 0.35 | 0.72 |
| Codominant model | TT vs. CC | 3 | 1.10 | 0.52-2.33 | 0 | 0.29 | 0.24 | 0.81 |
| TT vs. CT | 3 | 1.13 | 0.53-2.41 | 46 | 0.16 | 0.31 | 0.75 | |
| Recessive model | TT vs. CT+CC | 3 | 1.14 | 0.54-2.38 | 31 | 0.23 | 0.34 | 0.74 |
| Dominant model | TT+CT vs. CC | 4 | 0.98 | 0.77-1.25 | 0 | 0.74 | 0.14 | 0.89 |
| (CCTTT)n repeats* | ||||||||
| Allele Model | L vs. S | 2 | 1.20 | 0.99-1.46 | 0 | 0.75 | 1.83 | 0.07 |
| Codominant model | LL vs. SS | 2 | 1.41 | 0.95-2.11 | 0 | 0.84 | 1.69 | 0.09 |
| LL vs. SL | 2 | 1.09 | 0.77-1.54 | 0 | 0.88 | 0.49 | 0.63 | |
| Recessive model | LL vs. SL+SS | 2 | 1.19 | 0.86-1.65 | 0 | 0.76 | 1.07 | 0.29 |
| Dominant model | LL+SL vs. SS | 2 | 1.33 | 0.98-1.82 | 0 | 0.93 | 1.83 | 0.07 |
OR: odds ratio; CI: confidence interval. *repeat numbers divided into two groups: S (9-11 repeats) and L (12-18 repeats).