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. 2015 Sep 22;5:14118. doi: 10.1038/srep14118

Figure 4. Factorial concentration-response study of combination (17-AAG, Afungin, Trichostatin A) in a HCT116 spheroidal model.

Figure 4

(A) Profiles of SI values (%) for the spheroid model at multiple time points. The SI values are sorted in the same order as in Fig. 2 (although all concentrations here are 5 times higher). The black arrow indicates the concentration combination discovered during the original iterative search. (B) Concentrations corresponding to A expressed as fractions of the concentrations used in the iterative search.