Table 3. Best matching compounds in Connectivity Map (CMap) when using the mRNA gene expression signature of the combination (17-AAG, Afungin, Trichostatin A) as a query.
| Rank | Compound name and no of instances | mean score | p-value |
|---|---|---|---|
| 1 | Withaferin A (n = 4) | +0.70 | <10−5 |
| 2 | Geldanamycin (n = 15) | +0.58 | <10−5 |
| 3 | Alvespimycin (n = 12) | +0.56 | <10−5 |
| 4 | Tanespimycin (n = 62) | +0.49 | <10−5 |
| 5 | Monorden (n = 22) | +0.43 | <10−5 |
| 6 | Alcuronium chloride (n = 2) | −0.82 | 6·10−4 |
| 7 | Emetine (n = 4) | −0.62 | 8·10−4 |
| 8 | Flunixin (n = 5) | −0.59 | 8·10−4 |
| 9 | Disulfiram (n = 5) | +0.62 | 10−3 |
| 10 | Diethylstilbestrol (n = 6) | +0.54 | 10−3 |
The mean connection score shown is produced by the publicly available CMap signature matching algorithm. The ranking is first based on p-values provided and then on the mean score value which is based on n instances of the compound in the database.