Table 1. Virus shed by ferrets inoculated with or exposed to the human H7N9 influenza viruses.
| Virus | Infection route | Ferret | Virus shedding |
Seroconversion (HI titer at 14 dpi/13 dpe) | ||
|---|---|---|---|---|---|---|
| Start day (dpi/dpe) | Duration (days) | Peak titer (log TCID50/ml) [dpi/dpe]: PB2-627, 701 residues (percentage) | ||||
| A/Anhui/1/2013 | Inoculation | In-1 | 1 | 6 | 6.0 [2]: 627K(100%), 701D(100%) | 320 |
| In-2 | 1 | 6 | 6.3 [2]: 627K(100%), 701D(100%) | 640 | ||
| In-3 | 1 | 6 | 6.0 [2]: 627K(100%), 701D(100%) | 320 | ||
| Physical contact | PC-1 | 1 | 8 | 7.0 [4]: 627K(100%), 701D(100%) | 160 | |
| PC-2 | 1 | 6 | 5.0 [4]: 627K(100%), D701N(86.8%) | 320 | ||
| PC-3 | 3 | 4 | 6.0 [3]: 627K(100%), D701N(94.2%) | 320 | ||
| Airborne exposed | AE-1 | — | — | — | 40 | |
| AE-2 | 9 | 4 | 6.0 [10]: 627K(100%), 701D(100%) | 80 | ||
| AE-3 | 6 | 6 | 6.3 [7]: 627K(100%), 701D(100%) | 320 | ||
| A/Shanghai/05/2013 | Inoculation | In-1 | 1 | 6 | 5.3 [2]: 627E(100%), 701D(100%) | 80 |
| In-2 | 1 | 6 | 6.3 [2]: 627E(100%), 701D(100%) | 160 | ||
| In-3 | 1 | 6 | 6.0 [2]: 627E(100%), 701D(100%) | 80 | ||
| Physical contact | PC-1 | — | — | — | 40 | |
| PC-2 | — | — | — | 40 | ||
| PC-3 | 1 | 8 | 5.8[4]: 627E(100%), 701D(100%) 5.3[8]: E627K(30%), D701N(1.1%) | 80 | ||
| Airborne exposed | AE-1 | — | — | — | — | |
| AE-2 | — | — | — | — | ||
| AE-3 | — | — | — | — | ||
-: virus or HI antibody not detected. dpi/dpe: days post-inoculation or post-exposure. HI titer: heamagglutination inhibition titer. In-#: ferret intranasally inoculated with the virus; PC-#: ferret exposed to the infected animals via physical contact; AE-#: ferret exposed to the infected animals via airborne exposure.