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. 2015 Sep 23;5:14440. doi: 10.1038/srep14440

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Copyright © 2015, Macmillan Publishers Limited

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(a) The EM density map is shown in different orientations with the RNAP II core (yellow; pdbcode, 4A93³) and BRCT domain (gray; pdbcode, 1JNX⁶) positioned in the map. The RNAP II stalk domain that consists of subunits RBP4 and RPB7 is also shown within the density map. Scale bar is ~10 nm. (b) A close-up view of the BRCT domain (gray; pdbcode, 1JNX⁶) composed of BRCT1 and BRCT2 motifs displayed in two opposing views (b,c) with respect to the RNAP II subunits (yellow; pdbcode, 4A93³) that define the stalk domain (RPB4/RPB7). The RNAP II large subunit (RPB1) and its terminal residue defined in the crystal structure (P1455; black arrows) are also indicated. (d) Sections (1–6) through the BRCT domain positioned within the EM density map. Please also see Supplementary Movie 1.