Figure 3. Induction of therapeutic anti-tumor immunity.
C57BL/6J and BALB/c mice were treated with pFAP-transfected, pVector-transfected, or non-transfected tumor cells or n.s. on days 5, 12, and 19 after s.c. inoculating 1 × 106 B16F10 cells, LL/2 cells or CT26 cells into mice on day 0. (a–c) The tumor volume in the mice immunized with pFAP-transfected tumor cells or a control (*P < 0.05, **P < 0.01 or ***P < 0.001). (d–f) A significant increase in the survival of mice immunized with pFAP-transfected tumor cells, compared with the control mice, was observed in the three tumor models (P < 0.05). Points, mean (n = 10); bars, SD. Each experimental group was performed twice.