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. 2015 Sep 23;5:14421. doi: 10.1038/srep14421

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Copyright © 2015, Macmillan Publishers Limited

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(a) Tumor cell suspensions were stained with antibodies against CD11b (FITC), F4/80 (PE) and CD206 (PerCP) to identify TAMs. (b) Tumor cell suspensions were stained with antibodies against CD11b (FITC), and Gr-1 (PE) to identify MDSCs. (c) Splenocyte suspensions were stained with antibodies against CD4 (PerCP, cell surface) and FOXP3 (FITC, nuclear) to identify Tregs. (d) Splenocyte suspensions were stained with antibodies against CD8 (FITC) and CD4 (PE) to identify T lymphocytes. Vaccination with pFAP-B16F10 cells resulted in significantly decreased numbers of M2 macrophages, MDSCs and Tregs, accompanied by an increased number of CTLs, in the TME (*P < 0.05, **P < 0.01).