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. 2015 Sep 24;5:14447. doi: 10.1038/srep14447

Table 1. Summary of primary lesion and metastatic tumours.

Status1 Organ2 Histology EGFR TP534 PTEN4 PIK3CA4 RB14
Pre. Right lung Non-small cell lung cancer E746_A750del P151S wt E545K E458*
Post. Liver Small cell lung cancer E746_A750del P151S M264I wt wt
Post. Liver Adenocarcinoma E746_A750del+T790M P151S wt wt wt
Post. Left lung Small cell lung cancer E746_A750del n.d. wt n.d. n.d.
Post. Peri-panc. Adenocarcinoma E746_A750del+T790M n.d. wt n.d. n.d.
Post. Ret-LN 1 Small cell lung cancer E746_A750del n.d. wt n.d. n.d.
Post. Ret-LN 23 Small cell lung cancer E746_A750del n.d. n.d. n.d. n.d.
    Adenocarcinoma E746_A750del+T790M n.d. n.d. n.d. n.d.
Post IVC Small cell lung cancer E746_A750del n.d. wt n.d. n.d.
Post. Left AG Small cell lung cancer E746_A750del n.d. wt n.d. n.d.
Post. Left AG-inv. Small cell lung cancer E746_A750del n.d. wt n.d. n.d.

1Sample obtained from biopsy prior to gefitinib treatment (Pre.) or autopsy samples after gefitinib treatment failure (Post.).

2Peri-panc., Ret-LN, IVC, AG, and AG-inv. indicate peri-pancreatic lymph node, retroperitoneum lymph node, tumour embolism in inferior vena cava, adrenal grand, and adrenal grand invading part to retroperitoneum, respectively.

3Retroperitoneum lymph node 2 included each histology independently.

4n.d. indicates not done.