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. 2015 Sep 25;5:14270. doi: 10.1038/srep14270

Table 1. Summary of steady-state voltage-dependence of HCN channels with and without cholesterol modulation.

Isoform	Condition	V_1/2 (mV)	V_1/2 pre-pulse(mV)	k	k pre-pulse
HCN1	Control	−102 ± 3	−88 ± 3^*	10.1 ± 0.7	8.4 ± 0.9
	Depleted	−100 ± 3	−89 ± 2^*,^‡	11.2 ± 1.4	6.9 ± 0.6
	Mevastatin	−100 ± 6	−90 ± 8^*,^‡	18.1 ± 4.9	9.3 ± 0.7
	Enriched	−105 ± 3	−84 ± 4^*,^‡	10.5 ± 0.5	13.4 ± 2.0
HCN2	Control	−114 ± 3	−118 ± 2	11.4 ± 2.3	6.5 ± 1.5
	Depleted	−115 ± 5	−98 ± 3^*,^†,^‡	10.4 ± 1.8	11.6 ± 2.6
	Mevastatin	−118 ± 2	−108 ± 4^*,^†,^‡	17.8 ± 5.8	12.4 ± 1.6
	Enriched	−117 ± 4	−106 ± 2^*,^†,^‡	14.5 ± 1.7	7.5 ± 1.0
HCN4	Control	−121 ± 4	−111 ± 2^*	14.5 ± 2.0	13.2 ± 1.5
	Depleted	−111 ± 3^‡	−107 ± 4^‡	13.5 ± 0.7	12.3 ± 0.9
	Mevastatin	N.D.	N.D.	N.D.	N.D.
	Enriched	−108 ± 2^‡	−103 ± 2^*,^†,^‡	15.5 ± 2.2	14.2 ± 3.6

^‡P < 0.05 vs. control no pre-pulse.

*P < 0.05 vs no-prepulse.

^†P < 0.05 vs. control pre-pulse.