Table 2. Effect of nicorandil with or without glibenclamide co-administration on N-acetyl-β-D-glucosaminidase (NAG), histamine and leukotriene C4 (LTC4) levels in bronchoalveolar lavage fluid (BALF) from rats with cyclophosphamide (CP)-induced toxicity.

Groups	NAG(μmol p-nitrophenol/min/mg protein)	Histamine(μg/mg protein)	LTC4(μg/mg protein)
Normal	15.84 ± 1.32	77.79 ± 8.31	3.18 ± 0.27
CP	33.54 ± 2.01 a	159.63 ± 8.91 a	9.45 ± 0.72 a
CP + nicorandil	23.67 ± 1.68 ab	68.85 ± 6.36 b	5.28 ± 0.63 b
CP + nicorandil + glibenclamide	26.97 ± 1.86 a	174.81 ± 10.83 a	11.88 ± 0.51 a

Each value represents the mean of 5–8 experiments ± S.E.M. ^ap < 0.05 vs. normal, ^bp < 0.05 vs. CP.