Table 2. Comparative analysis of combination responses in Dd2 as judged by single point Chou-Talalay analysis for selected drug combinations at IC50 and LD50 concentrations (n = 3, +/− SEM values provided in SI) and at the anticipated in vivo concentration (AIVC). Values for HB3 are provided in table S8.
| Drug Combination | Avg. FIC |
Avg. FICIndex | Avg. FLD |
Avg. FLDIndex | Avg. FAIVCa |
Avg. FAIVCIndex | |||
|---|---|---|---|---|---|---|---|---|---|
| Drug A | Drug B | Drug A | Drug B | Drug A | Drug B | ||||
| ATM + LUM | 0.67 | 0.47 | 1.1 (Add.) | 0.42 | 0.58 | 1.0 (Syn.) | ND | ND | ND |
| ATM + GSK-2126458 | 0.54 | 0.52 | 1.1 (Add.) | 0.18 | 0.21 | 0.39 (Syn.) | ND | ND | ND |
| ATM + NVP-BGT226 | 0.97 | 1.05 | 2.0 (Add.) | 0.27 | 0.46 | 0.93 (Syn.) | 0.85 | 0.14 | 0.99 (Syn.) |
| ATM + Torin 2 | 0.75 | 0.59 | 1.3 (Add.) | 0.54 | 0.60 | 0.94 (Syn.) | ND | ND | ND |
| LUM + GSK-2126458 | 0.27 | 0.40 | 0.67 (Syn.) | 0.20 | 0.15 | 0.35 (Syn.) | ND | ND | ND |
| LUM + NVP-BGT226 | 0.60 | 0.93 | 1.5 (Add.) | 1.10 | 1.17 | 2.0 (Ant.) | 0.45 | 0.05 | 0.49 (Syn.) |
| LUM + Torin 2 | 0.44 | 0.48 | 0.9 (Syn.) | 0.50 | 0.19 | 0.5 (Syn.) | ND | ND | ND |
aData indicates a ratio of ATM:NVP-BGT226 of 100:1 and a ratio of LUM:NVP-BGT226 of 500:1. Additional ratios for ATM:NVP-BGT226 include 50:1, 200:1, and 400:1 and for LUM:NVP-BGT226 include 250:1, 1250:1, and 25000:1. These data are presented in table S8. FIC (fractional inhibitory concentration); FLD (fractional lethal dose); FAIVC (fractional anticipated in vivo concentration); ATM (artemether); LUM (lumefantrine); Add. (additive); Syn. (synergistic); Ant. (antagonistic).