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. 2015 Sep 25;5:14352. doi: 10.1038/srep14352

Figure 2. Oligomers in PLY crystals.

Figure 2

(a) Crystal packing of PLY monomers. The monomers are arranged in a linear array. (b) Zoomed in view of the monomer-monomer interface in the PLY oligomer shown in panel (a) with residues that were mutated highlighted in yellow and contacting residues in red or blue spheres depending from which monomer they originated. (c) Steps in the formation of a tightly-packed linear CDC oligomer. PLY was modelled on to the structures of the ILY-CD59 complex and LLO crystal structures by separate superimposition of domains 1 to 3 and domain 4 of PLY on to two adjacent monomers in the ILY and LLO linearly packed crystallographic oligomers. Shown from left to right: the relative orientation of PLY modelled on the ILY-CD59 oligomer, the LLO oligomer and the actual orientation within the PLY oligomer itself. A contraction of the dimer and the straightening of the domains 1, 2, 3 – domain 4 angle occurs in going from left to right.