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. 2015 Sep 28;5:14573. doi: 10.1038/srep14573

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Copyright © 2015, Macmillan Publishers Limited

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(A) One week after PPVL, five weeks after BDL or fifteen weeks after CCl₄-intoxication, rats received atorvastatin or control chow for 7 days before sacrifice. (B) Portal pressure was decreased in CCl₄ rats and significantly upregulated in PPVL rats. (C) Hepatic vascular resistance was significantly downregulated in CCl₄ as well as in PPVL rats. (D) Splanchnic vascular resistance remained unchanged in CCl₄ rats and was significantly decreased in PPVL rats. (E) Shunt flow was decreased in CCl₄ rats and significantly enhanced in PPVL rats after statin treatment compared to control. (F) Systemic vascular resistance was significantly reduced in PPVL rats and remained unchanged in CCl₄-intoxicated rats. (G) In PPVL, as well as in CCl₄-intoxicated rats, cardiac output was increased.