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. 2015 Sep 28;5:14573. doi: 10.1038/srep14573

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Copyright © 2015, Macmillan Publishers Limited

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(A) Shh mRNA levels were highly upregulated in hepatic arteries of liver transplant recipients compared to donors. (B) Shh mRNA levels were downregulated in subcutaneous implanted matrigel of BDL rats after atorvastatin treatment. Gli-2 was highly upregulated in subcutaneous implanted matrigels of PPVL rats. (C) Shh mRNA levels were reduced in intraperitoneal implanted matrigel of BDL and CCl₄-intoxicated rats after statin treatment and Gli-2 was highly upregulated in PPVL rats. (D) Atorvastatin reduced migration of A7r5 rat aortic VSMCs significantly in vitro. Incubation with cyclopamine had no effect on migration capability of VSMCs. (E,F) Endothelial cells (HUVEC) formed more tubes after incubation with atorvastatin in tube formation assay.