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. 2015 Sep 28;5:14503. doi: 10.1038/srep14503

Figure 2. rh-Endo normalizes ESCC vascularization in vivo.

Figure 2

Tumor tissues from mice in the four treatment groups were removed and stained with anti-CD31, anti-CD105, anti-Lectin and anti-α-SMA antibodies on days 10, 16 and 22 (D10, D16 and D22) after transplantation of ECA109 cells. (a) Representative images of CD31 immunostaining (used as a microvessel marker). (b) Microvessel densities determined from CD31 immunostaining in the various experimental groups. (c) Representative images showing immunostaining for CD105 (a marker of new vessels), Lectin (a marker of functional vessels) and α-SMA (a marker of pericyte coverage). (d) Integral optical densities (IODs) of the various experimental groups (upper, CD105; middle, Lectin; lower, α-SMA) on D22 (the end of the treatment period). *P < 0.05 vs. IR group, **P < 0.01 vs. IR group.