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Schematic illustrating the interrelations between macroautophagy and CMA. Macroautophagy and CMA communicate with each other in the process of autophagy-lysosomal degradation. CMA blockage can induce compensative upregulation of macroautophagy, and the CMA pathway compensates when macroautophagy is inhibited. Molecular directors such as hsc70, Nrf2, ubiquilin, and p53 may function as core network nodes in macroautophagy-CMA crosstalk
