Table 3. Results of analyses of the association of candidate biomarkers with mortality among patients with advanced Chagas cardiomopathy (Stage D) using receiver operating characteristic curves and Cox regression models.
| Crude model | Adjusted model2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Biomarker | AUC1 | Cut-off1 (pg/ml) | Status | Median (IQR) biomarker level in pg/ml | N (%) above cutoff | P | HR1 (95% CI) | P | HR (95% CI) |
| BNP3 | 0.61 | 184.1 | Alive | 109 (9-263) | 11 (37%) | 0.039 | 2.8 (1.1-7.2) | 0.025 | 3.1 (1.2-8.4) |
| Died | 267 (37-347) | 14 (70%) | |||||||
| NTproBNP3 | 0.66 | 765.1 | Alive | 425 (288-740) | 5 (16.7 %) | 0.002 | 4.1 (1.6-10.0) | 0.002 | 4.4 (1.8-11.0) |
| Died | 777 (423-1310) | 11 (55%) | |||||||
| CKMB3 | 0.56 | 8300 | Alive | 3994 (3447-7487) | 5 (17%) | 0.005 | 3.5 (1.6-8.5) | 0.009 | 3.3 (1.3-8.0) |
| Died | 7534 (2960-11,438) | 10 (50%) | |||||||
| MMP-23 | 0.72 | 103980 | Alive | 94,680 (75,549-111,884) | 9 (30%) | 0.008 | 4.0 (1.4-11.2) | 0.007 | 4.2 (1.5-11.8) |
| Died | 126,828 (96,148-164,256) | 14 (74 %)4 | |||||||
1
Area under the curve (AUC), cutoffs and hazard ratios (HRs) based on receiver operating characteristic (ROC) curves. Hazard ratios were only calculated for those with AUC greater than 0.55.
2
Model adjusted for age and sex.
3
BNP, Brain Natriuretic Peptide; NTproBNP, N-terminal brain natriuretic peptide; CKMB, Creatine kinase-MB; MMP2, Matrix metalloproteinase 2.
4
MMP2 data were missing for one individual who died