. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: J Hepatol. 2014 Sep 10;62(2):286–293. doi: 10.1016/j.jhep.2014.08.052

Table 3.

Predictors of anaemia (haemoglobin <10 g/dl) among HCV genotype 1 patients adjusted for gender and age.

Risk factor	Boceprevir patients (n = 455)		Telaprevir patients (n = 1629)		All patients (n = 2084)
Risk factor	OR	95% CI	OR	95% CI	OR	95% CI
Female gender²	3.55	(2.33, 5.42)	2.95	(2.37, 3.68)^*	3.05	(2.52, 3.71)^*

Cirrhosis	1.11	(0.72, 1.73)	1.36	(1.09, 1.69)	1.29	(1.06, 1.57)

Total bilirubin (mg/dl)	0.98	(0.66, 1.46)	1.13	(0.92, 1.38)	1.09	(0.91, 1.31)

Age³	1.05	(1.03, 1.07)	1.06	(1.04, 1.07)^*	1.06	(1.04, 1.07)^*

HCV RNA (lnsIU)	1.02	(0.93, 1.12)	1.00	(0.94, 1.06)	1.00	(0.95, 1.05)

Creatinine clearance¹ (ml/min)	0.99	(0.98, 0.99)^*	0.99	(0.99, 0.99)^*	0.99	(0.99, 0.99)^*

Diabetes	1.20	(0.71, 2.03)	0.89	(0.66, 1.20)	0.97	(0.75, 1.26)

IL28B genotype CC	0.81	(0.41, 1.57)^*	1.04	(0.70, 1.55)	0.97	(0.69, 1.36)

Treatment experience	0.91	(0.59, 1.39)	0.84	(0.68, 1.05)	0.85	(0.71, 1.03)

Albumin (<3.5 g/dl)	1.23	(0.58, 2.61)	1.6	(1.12, 2.29)	1.52	(1.1, 2.1)

HCV genotype 1a	0.70	(0.43, 1.14)	0.74	(0.57, 0.96)^*	0.73	(0.58, 0.91)^*

Haemoglobin	0.55	(0.45, 0.66)^*	0.61	(0.55, 0.67)^*	0.60	(0.55, 0.65)^*

Platelets (≤100,000 mm³ n/μl)	1.54	(0.87, 2.75)	1.81	(1.37, 2.39)^*	1.74	(1.35, 2.23)^*

Rows were selected by a stepwise variable selection method.

estimated using Cockcroft-Gault formula.

adjusted for age.

adjusted for gender.