Figure 3. Transcriptional changes induced by exercise training and by selective breeding for longevity are highly overlapping.

(A) Venn diagram showing transcripts altered by breeding from Ra to La (beige), transcripts altered by exercise training Ra males (blue), and the transcripts commonly altered by both interventions (overlap). (B) Plot of variance in gene expression explained by each treatment, when each is treated as the principal component (PCA). Training creates an expression pattern in Ra that is substantially similar to La. Ra (green), exercise trained Ra (blue) and selectively bred La (red). (C) Heat map of genes contained in KEGG pathways that are significantly altered by both interventions.