Table 1. KEGG pathway transcripts altered in the same direction by both endurance exercise and longevity selection.
| Pathway | Hits | KEGG ID | |
|---|---|---|---|
| Upregulated KEGG pathway genes | metabolism of xenobiotics drug metabolism | 10 | Ugt37b1, Ugt37a1, [GstD2, GstD5, GstD8, GstD3, GstE1, GstE2, GstE3, GstE5] |
| [glutathione metabolism] | 8 | ||
| folate biosynthesis | 3 | CG3290, CG5150, CG10592 | |
| Downregulated KEGG pathway genes | starch/sucrose metabolism• | 8 | CG12766•, CG9914•, CG5171•, Mal-A4•‡, Mal-B1•‡, Amy-d•‡, Amyrel•‡, Mal-A7•*, CG10178*, Ugt35b*, Ug86Dd* |
| galactose metabolism‡ | 4 | ||
| pentose/glucuronate interconversions* | 4 | ||
| limonene/pinene degradation | 5 | Cyp4ac3, Cyp6a8, Cyp309a2, Cyp12a5, Cyp4p1 |
Brackets indicate genes that are members of both the glutathione metabolism and the metabolism of xenobiotics KEGG pathways. Gray upregulated genes are part of the KEGG folate biosynthesis pathway. Dots, crosses and stars indicate membership in downregulated KEGG pathways. Some genes are members of multiple pathways. Gray downregulated genes are members of the KEGG limonene/pinene degradation pathway.