Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 28;10(9):e0138913. doi: 10.1371/journal.pone.0138913

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Awan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Fig 1 — Liver-specific proteins extracted from various databases were screened using SignalP 4.1, SecretomeP 2.0, ExoCarta, TargetP 1.1 and TMHMM v. 2.0 servers to assess their secretory nature. Liver-specific secreted proteins once verified for their expression in liver (HPA and BioGPS) and blood (Plasma Proteome Database) were further prioritized depending upon their presence in secretome proteome of HCC patients, HCC cell lines and primary human hepatocytes. To infer possible involvement of prioritized proteins in HCC pathogenesis, their interactome analysis was done with AFP (as a standard biomarker for the diagnosis of HCC). Interacting proteins were then analysed for their interaction with HCC specific liver deregulated and circulating miRNA. Results were then statistically verified using SurvExpress validation tool to finally prioritize putative circulating biomarkers for HCC.