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. 2015 Sep 28;10(9):e0138913. doi: 10.1371/journal.pone.0138913

Fig 4. Interactome network analysis (protein-protein).

Fig 4

Interactome analysis of candidate proteins with current standard HCC biomarker AFP was retrieved by tools: GeneMANIA (A & B), STRING (C & D). Interacting partners of AFP (TP53, FOXA1, FOXA3, GPC3, IGFBP1, NR3C1, F2, AHSG, ACTL6A and JUN) along with DKK1 and MDK are also main elements of the interactome. The size of the gray nodes in Fig 4A and 4B represents the degree of association with the input genes (i.e., smaller size represents less association).