Table 2. Liver-specific secreted/shed proteins identified by each database utilized in this study.

Gene	TiSGeD	TiGER	UniGene	C-it	VeryGene	BioGPS	HPA	Reference
ADH6	√	√			√			Secretome of primary human hepatocytes [37]
ANG	√	√			√	√		Previously studied as biomarker [59]
APOA5			√		√	√	√	Secretome of HCC cell line [36]
APOC3	√	√			√	√		Secretome of primary human hepatocytes [37]
APOC4	√	√	√		√	√	√
APOF	√		√		√	√	√
ASL	√					√		Secretome of primary human hepatocytes [37]
C4A	√	√				√		Previously studied as biomarker [1]
C8A	√	√	√		√	√	√	Secretome of HCC (Hep3B, serum) [40, 44]
CFHR4	√				√	√	√	Previously studied as biomarker [60]
CYP2A6	√	√	√		√	√	√	Secretome of primary human hepatocytes [37]
CYP2A7	√	√			√	√
CYP2C18		√			√	√
CYP2E1	√	√	√		√	√	√
CYP4A22	√				√	√
F10	√				√	√		Secretome of HCC cell lines [36, 41]
F9		√	√		√	√	√
FCN2	√				√	√
GCKR	√				√	√
GSTM1	√				√	√		Normal and HCC liver tissue [37]
HAMP	√				√	√
HP	√	√	√		√	√	√	Previously studied as biomarker [61]
HRG	√	√	√		√	√	√	Previously studied as biomarker [37]
HSD11B1	√				√	√		Secretome of primary human hepatocytes [37]
ITIH4	√	√			√	√	√	Previously studied as biomarker [62]
MBL2			√		√	√	√	Secretome of HCC cell lines (Hep3B, HepG2) [41]
NR0B2	√	√				√
PLGLB2		√	√		√	√	√
PON3	√	√			√	√
RDH16	√	√			√	√	√	Secretome of primary human hepatocytes [37]
SERPINC1	√	√	√		√	√	√	Secretome of HCC serum [43]
SLC25A47			√	√	√	√	√
SLC27A5	√	√			√	√
SPP2		√	√	√	√	√	√
TFR2		√			√	√		Secretome of HCC (Cell line Hep3B) [40, 41]
TMPRSS6		√			√	√
UPB1	√	√			√	√		Secretome of primary human hepatocytes [37]
VTN	√	√			√	√		Previously studied as biomarker [63, 64]