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. 2015 Sep 28;10(9):e0138913. doi: 10.1371/journal.pone.0138913

Table 3. Seven statistically significant putative HCC specific biomarkers prioritized through integrated in-silico approach.

Gene Biological functions HCC-specific deregulated miRNAs (Liver) (Circulating)
ADH6 Metabolism of xenobiotics by cytochrome P450, drug metabolism, glycolysis/gluconeogenesis, tyrosine metabolism, metabolic pathways, retinol metabolism and fatty acid metabolism. hsa-miR-182, hsa-miR-185, hsa-miR-203, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-146a, hsa-miR-211, hsa-miR-150 hsa-miR-199a-5p, hsa-miR-146a, hsa-miR-150
UPB1 Beta alanine metabolism, metabolic pathway, pantotheanate and CoA biosynthesis, drug metabolism-other enzymes and pyrimidine metabolism. hsa-miR-216a, hsa-miR-181c, hsa-miR-181a, hsa-miR-181b, hsa-miR-134, hsa-let-7e, hsa-let-7b, hsa-let-7a, hsa-let-7c, hsa-let-7f, hsa-let-7g, hsa-let-7d, hsa-miR-224 hsa-let-7f, hsa-let-7c, hsa-miR-224
C8A Complement and coagulation cascades, prion disease, systemic lupus erythematosus and amoebiasis. hsa-miR-212, hsa-miR-132, hsa-miR-93, hsa-miR-106a, hsa-miR-106b, hsa-miR-17, hsa-miR-20a, hsa-miR-302b, hsa-miR-26a, hsa-miR-26b, hsa-miR-145, hsa-miR-148a, hsa-miR-148b, hsa-miR-152, hsa-miR-186, hsa-miR-129-5p hsa-miR-93, hsa-miR-17, hsa-miR-520a-3p, hsa-miR-520b, hsa-miR-26a,
HSD11B1 Steroid hormone biosynthesis, metabolic pathways, and in aldosterone-regulated sodium reabsorption. hsa-miR-181c, hsa-miR-181a, hsa-miR-181b, hsa-miR-374a, hsa-miR-374b, hsa-miR-192, hsa-miR-215, hsa-miR-23a, hsa-miR-23b, hsa-miR-132, hsa-miR-212, hsa-miR-26a, hsa-miR-26b, hsa-mir-122, hsa-mir-125a, hsa-mir-125b-1, hsa-mir-125b-2, hsa-mir-145, hsa-mir-222 hsa-miR-192, hsa-miR-215, hsa-miR-23a, hsa-miR-23b, hsa-miR-26a, hsa-mir-122, hsa-mir-222
MBL2 Complement and coagulation cascades, acute-phase response, classical pathway, negative regulation of viral process, opsonization, positive regulation of phagocytosis. hsa-miR-320c, hsa-miR-374b, hsa-miR-374a, hsa-miR-186, hsa-miR-200b, hsa-miR-301a, hsa-miR-301b, hsa-miR-137, hsa-miR-23a, hsa-miR-23b, hsa-miR-206, hsa-miR-216b, hsa-miR-30a, hsa-miR-30e, hsa-miR-30c, hsa-miR-146a, hsa-miR-190b, hsa-miR-190, hsa-miR-130a, hsa-miR-130b, hsa-miR-148a, hsa-miR-148b, hsa-miR-152, hsa-miR-145, hsa-miR-196a, hsa-miR-216a, hsa-miR-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7a-1, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-2, hsa-let-7g, hsa-mir-1-2, hsa-mir-1-1, hsa-mir-10a, hsa-mir-125b-1, hsa-mir-125b-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-16-2, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-99a hsa-miR-23a, hsa-miR-23b, hsa-miR-30c, hsa-miR-146a, hsa-miR-130b, hsa-miR-1, hsa-miR-206, hsa-let-7f-2, has-let-7c, hsa-mir-16-1, hsa-mir-16-2
SERPINC1 Complement and coagulation cascades, neuroactive ligand receptor interaction and regulation of actin cytoskeleton. hsa-miR-186, hsa-miR-19a, hsa-miR-19b, hsa-miR-143, hsa-miR-7 hsa-miR-7
CYP2A6 Drug metabolic process, epoxygenase P450 pathway, exogenous drug catabolic process, oxidation-reduction process, small molecule metabolic process, steroid metabolic process, xenobiotic metabolic process. hsa-mir-101-1, hsa-mir-101-2, hsa-mir-126, hsa-mir-199a-1, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-34a hsa-mir-199a-1, hsa-mir-199a-2