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. Author manuscript; available in PMC: 2016 Jun 23.
Published in final edited form as: Cell Rep. 2015 Jun 11;11(11):1714–1726. doi: 10.1016/j.celrep.2015.05.032

Figure 1. Virus-encoded siRNAs do not impose further attenuation on mIAV.

Figure 1

(A) Quantitative RT-PCR (qPCR) of IFIT1, IFIT2, and IFNb in A549 cells either mock treated or infected (MOI=0.1) with mIAV, mIAV-siGFP, or wtIAV. Error bars, SD, *p<0.05.

(B) Multi-cycle growth curves in A549s infected (MOI=0.01) with mIAV, mIAV-siGFP, or wtIAV. Error bars, SD, *p<0.05.

(C) Virus lung titers of wild type or Ifnar1−/− B6 mice infected with either the mIAV-siGFP, or wtIAV viruses. Mice were infected with 1 × 106 pfu of each virus and lungs were harvested 24 hpi. Error bars, SD, *p<0.05.