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. Author manuscript; available in PMC: 2016 Jun 23.
Published in final edited form as: Cell Rep. 2015 Jun 11;11(11):1714–1726. doi: 10.1016/j.celrep.2015.05.032

Figure 4. Infection with the library in mice selects for a virus targeting Ifih1.

Figure 4

(A) Graphical depiction of siRNA composition derived from deep sequencing data of mice infected with 1 × 104 pfu of the pooled library. Left side of each graph represents the proportion of unique viral strains, as defined by their siRNA. Right side of each graph depicts in vivo selection dynamics following four days of infection.

(B) Levels of virus replication from mice infected with 1 × 106 pfu of mIAV-siGFP or -siIfih1 and assessed at the indicated time points. Error bars, SD, *p<0.05.

(C) Lung titers from wild-type or Ifih1−/− mice infected with 1 × 106 pfu of mIAV-siGFP or -siIfih1 as measured 24 hours post infection. Error bars, SD, *p<0.05.

(D) Lung titers from wild-type mice or Ifih1−/− mice infected with 1 × 104 pfu of wtIAV or mIAV measured 48 hours post infection. Error bars, SD, *p<0.05.