Protein–protein interactions among the RecQ helicases. The vertical panel to the left lists six DNA metabolic pathways and the RecQ helicases that participate in those pathways. Each RecQ helicase is represented as a colored hexagon. The interacting proteins are shown next to each RecQ helicase. Proteins that interact with four or five RecQ helicases are represented by light blue ovals, and proteins that interact with two or more RecQ helicases are represented by white ovals. Abbreviations: BER, base excision repair; DSBR, double-strand break repair; mRNA, messenger RNA; Topo, topoisomerase.