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RecQ helicases in DNA replication. Putative roles of RecQ helicases during initiation of DNA replication, Okazaki fragment processing, leading- and lagging-strand elongation, fork restart, and regression are indicated. The orange star and triangle denote polymerase blocking DNA damage. In addition, RECQL5 may specifically inhibit transcription to prevent replication and transcription fork collisions. Abbreviations: RQ1, RECQL1 helicase; RQ4, RECQL4 helicase; RQ5, RECQL5 helicase.
