Skip to main content
. Author manuscript; available in PMC: 2015 Sep 29.
Published in final edited form as: Annu Rev Biochem. 2014 Mar 3;83:519–552. doi: 10.1146/annurev-biochem-060713-035428

Figure 5.

Figure 5

RecQ helicases (BLM, WRN, and RECQL4) in telomere maintenance and repair. Interactions with shelterin proteins (TRF1, TRF2, and POT1) and resolution of secondary structures that are potential barriers to telomere replication are shown. RecQs may resolve inter- and intratelomeric substrates, G quadruplexes (G4s), and telomeric T-loops and D-loops. Abbreviations: BIR, break-induced replication; HJ, Holliday junction; RPA, replication protein A; RQ4, RECQL4; TIN2, TRF1-interacting nuclear factor 2; TPP1, POT1-interacting telomere end–binding protein.