Table 4.
Study population | No. of cases/controls | Main effects of polymorphisms
|
Gene–environment interaction | References | ||
---|---|---|---|---|---|---|
OGG1 Ser326Cys | XRCC1 (Arg399Gln, Arg194Trp, Arg280His) | APE1Asp148Glu | ||||
Turkish (H) | 100/100 | 2.5-fold IR (Cys/Cys) | NA | – | Not interaction with smoking | Karahalil et al.80 |
Caucasian (H) | 609/613 | NA | PE (Arg/Trp + Trp/Trp) | NA | IR (Cys/Cys) (ever smokers) No interactions (Others) | Huang et al.64 |
American (H) | 539/524 | NA | NA (Arg/Gln, Arg/Trp) -(Arg/His) | – | RR (Ser/Cys) (ever smokers) | Huang et al.64 |
–: Unreported; NA; no association; IR: increased risk; RR: reduced risk; PE: protective effect; S: smoking; RM: red meat; H: hospital based study.