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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Behav Pharmacol. 2015 Oct;26(7 0 0):654–663. doi: 10.1097/FBP.0000000000000155

Figure 1.

Figure 1

Effects of acute SDS (A), chronic SDS (B), and chronic SDS with 35 days of imipramine (IMIP) treatment or saline (VEH) treatment on pDYN and KOR mRNA levels in the NAc. Top row: Experimental design depicting the time course of the SDS regimen and social interaction (SI) for each qPCR experiment. Middle row: pDYN mRNA data. Bottom row: KOR mRNA data. (A) Acute SDS elevated pDYN mRNA, and a similar trend was observed for KOR mRNA (n’s=5–6). (B) Chronic SDS decreased pDYN mRNA in both susceptible and resilient mice. A similar trend was observed for KOR mRNA levels (n’s=6–10). (C) Chronic SDS-induced decreases in proDYN were reversed by chronic (35 days) daily IMIP treatment, with a similar trend observed in KOR mRNA (n’s=6–8). *P<0.05 compared to controls; data are expressed as -fold differences in mRNA relative to GAPDH.