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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Behav Pharmacol. 2015 Oct;26(7 0 0):654–663. doi: 10.1097/FBP.0000000000000155

Figure 3.

Figure 3

Effects of pre-treatment with the KOR antagonist JDTic (30 mg/kg,i.p.) on ICSS behavior following SDS. (A) Average thresholds for baseline days (BL1-5), post-injection day (PI) and defeat days (D1-10) in mice pre-treated with VEH and JDTic 24 h before the SDS regimen. JDTic pre-treatment had no effect on ICSS thresholds on its own (PI day). SDS increased reward thresholds in both VEH and JDTic pre-treated mice; n=7–8 per group. (B) SDS increased ICSS thresholds over time in both groups. (C) There were no group differences on Day 10. (D) Maximum (Max) rates of responding decreased over time on Day 1, but there were no group differences. (E) There were no group differences in maximum rates on Day 10. *P<0.05, ***P<0.001; data are expressed as mean (+/− SEM) percent change from baseline (pre-SDS) values.