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Trans-disubstituted epoxy alcohol cyclizations under [Rh(CO)2Cl]2 and (±)-CSA promotion
| ||||
|---|---|---|---|---|
| entry | substrate | activator | 7/8 | yield 7 (%)a |
| 1 | 6a, n = 0 | [Rh(CO)2Cl]2b | >20 : 1 | 94 |
| 2 | 6a, n = 0 | (±)-CSAc | 1 : 1 | – |
| 3 | 6b, n = 1 | [Rh(CO)2Cl]2d | >20 : 1 | 81 |
| 4 | 6b, n = 1 | (±)-CSAe | 1 : 3 | – |
Isolated yield.
[Rh(CO)2Cl]2 (2.5 mol %), THF, rt.
(±)-CSA (10 mol %), CH2Cl2, rt.
[Rh(CO)2Cl]2 (5 mol %), THF, rt.
(±)-CSA (100 mol %), CH2Cl2, rt.
